Manchester Asthma and Allergy Study

ISRCTN	ISRCTN72673620
DOI	https://doi.org/10.1186/ISRCTN72673620
Secondary identifying numbers	N/A

Prospectively registered

Protocol

Statistical analysis plan

Results

Individual participant data

Plain English Summary

Not provided at time of registration

Prof Adnan Custovic
Scientific

North West Lung Research Centre
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom

Phone	+44 (0)161 291 2494
Email	adnan.custovic@manchester.ac.uk

Study design	Prospective observational birth cohort study
Primary study design	Observational
Secondary study design	Cohort study
Study setting(s)	Not specified
Study type	Other
Participant information sheet	Not available in web format, please use the contact details below to request a patient information sheet
Scientific title	Manchester Asthma and Allergy Study
Study acronym	MAAS
Study hypothesis	Birth cohort study investigating the development of asthma and allergic disease
Ethics approval(s)	1. Age 0 - 5 years follow up, ERP/94/032, approval received on 24/03/1994 2. Age 5 - 8 years follow up, SOU/00/258 and SOU/00/259, approval received on 20/12/2000 3. Age 8 - 11 years follow up, 03/SM/400, approval received on 05/12/2003
Condition	Asthma and allergy
Intervention	This is a prospective, observational birth cohort study, which includes investigating environmental exposures, immune responses, behaviour or family functioning, genetic epidemiology, pulmonary physiology and clinical outcomes
Intervention type	Other
Primary outcome measure	1. Asthma at age 5, 8, 11 and 14 years 2. Sensitisation at age 1, 3, 5, 8, 11 and 14 years 3. Allergies (e.g. hay fever) at age 5, 8, 11 and 14 years
Secondary outcome measures	1. Wheeze and eczema at age 1, 3, 5, 8, 11 and 14 years 2. Healthcare utilisation by age 8 - 11 years
Overall study start date	01/09/1995
Overall study end date	01/06/2019

Participant type(s)	Patient
Age group	Child
Sex	Both
Target number of participants	1250
Participant inclusion criteria	Children born at Wythenshawe Hospital, Manchester and Stepping Hill Hospital, Stockport between January 1996 and April 1998
Participant exclusion criteria	Premature birth <32 weeks gestation
Recruitment start date	01/09/1995
Recruitment end date	01/06/2019

Wythenshawe Hospital

Manchester
M23 9LT
United Kingdom

Wythenshawe Hospital (UK)
Hospital/treatment centre

c/o Andrew Maines
Research and Development Directorate
ERC Building
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
England
United Kingdom

Phone	+44 (0)161 291 5775
Email	andrew.maines@manchester.ac.uk
"ROR"	https://ror.org/05vpsdj37

Charity

Asthma UK (UK)
Private sector organisation / Other non-profit organizations

Moulton Charitable Trust (UK)

No information available

Intention to publish date
Individual participant data (IPD) Intention to share	No
IPD sharing plan summary	Not provided at time of registration
Publication and dissemination plan	Not provided at time of registration
IPD sharing plan

Output type	Details	Date created	Peer reviewed?	Patient-facing?
Results article	results	15/06/2008	Yes	No
Results article	results	01/06/2010	Yes	No
Results article	results	01/12/2015	Yes	No
Results article	results	15/10/2018	Yes	No

11/02/2019: Publication reference added.
05/05/2016: Publication reference added.