Acoustic analysis of the effect of codeine on cough in asthma and chronic obstructive pulmonary disease
| ISRCTN | ISRCTN57615270 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN57615270 |
| Secondary identifying numbers | N0226093097 |
- Submission date
- 12/09/2003
- Registration date
- 12/09/2003
- Last edited
- 12/05/2008
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Respiratory
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English Summary
Not provided at time of registration
Contact information
Prof Ashley Woodcock
Scientific
Scientific
North West Lung Centre
South Manchester University Hospitals NHS Trust
Wythenshawe Hospital
Southmoor Road
Manchester
M23 9LT
United Kingdom
| Phone | +44 (0)161 291 5873 |
|---|---|
| ashley.woodcock@manchester.ac.uk |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Treatment |
| Scientific title | |
| Study hypothesis | 1. To validate cough programme in the clinical setting (both in hospital and in the home environment) 2. To determine the specificity and sensitivity of the technique 3. To develop the programme further using more advanced sound analysis to improve detection and recognition of cough 4. To test the programme's ability to detect the effect of codeine linctus |
| Ethics approval(s) | Not provided at time of registration |
| Condition | Chronic obstructive pulmonary disease (COPD) |
| Intervention | Codeine phosphate 60 mg or matched placebo were given, in random order, at the start of each cough recording (0 and 12 hours). |
| Intervention type | Drug |
| Pharmaceutical study type(s) | |
| Phase | Not Specified |
| Drug / device / biological / vaccine name(s) | Codeine |
| Primary outcome measure | The number of coughs in each group before and after codeine, both in hospital and at home. |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 01/10/2002 |
| Overall study end date | 31/05/2003 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 21 |
| Participant inclusion criteria | 21 patients with physician-diagnosed, stable disease who complained of cough. |
| Participant exclusion criteria | Not provided at time of registration |
| Recruitment start date | 01/10/2002 |
| Recruitment end date | 31/05/2003 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
North West Lung Centre
Manchester
M23 9LT
United Kingdom
M23 9LT
United Kingdom
Sponsor information
Department of Health (UK)
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
| Website | http://www.doh.gov.uk |
|---|
Funders
Funder type
Charity
North West Lung Centre Charity (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | Results | 01/04/2006 | Yes | No |
