Predictors of psychological treatment outcomes for common mental health problems (CMHP) in Improving Access to Psychological Therapies (IAPT) service users
| ISRCTN | ISRCTN10670435 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN10670435 |
| IRAS number | 297739 |
| Secondary identifying numbers | IRAS 297739, CPMS 51250 |
- Submission date
- 21/12/2022
- Registration date
- 22/12/2022
- Last edited
- 15/08/2024
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Mental and Behavioural Disorders
Plain English Summary
Background and study aims
Psychological therapies are helpful in treating depression and anxiety and half of the treated adults do recover. However, it is not clear whether older people are helped more or less than younger people. In this study, we aim to investigate the predictors of psychological treatment outcomes for common mental health problems in adults (18+ years) in the IAPT services and secondly, whether these predictors affect psychological treatment outcomes differently for working age (18-64 years) and older adults (65+ years).
Who can participate?
The study aims to recruit 700 participants in total, who are aged 18 years or over and are offered treatment in the IAPT service for common mental health problems.
What does the study involve?
Participants will be asked to complete a baseline questionnaire before the start of their treatment. These baseline measures will be complemented by routinely collected data from the IAPT systems after the completion of treatment.
What are the possible benefits and risks of participating?
By taking part in the study, participants will help us learn for whom treatment for common mental health problems works best or least. This will help NHS services plan what to offer to others. Thinking about our thoughts and feelings of low mood and anxiety, stressful life events and their impact can be helpful. However, it can also be difficult to do. If a participant feels upset answering any of the questions,
When is the study starting and how long is it expected to run for?
December 2021 to March 2024
Where is the study run from?
University of Sussex (UK)
Who is funding the study?
Mental Health Research UK
Who is the main contact?
Alexandra Schmidt, as2085@sussex.ac.uk
Contact information
Principal Investigator
University of Sussex
Pevensey 1, 2C1
Falmer
Brighton
BN1 9QH
United Kingdom
 ORCID ID |
0000-0002-4359-6284 |
|---|---|
| Phone | +44 7810870572 |
| as2085@sussex.ac.uk |
Study information
| Study design | Multi-centre observational cohort study |
|---|---|
| Primary study design | Observational |
| Secondary study design | Cohort study |
| Study setting(s) | Home, Other therapist office, Telephone |
| Study type | Treatment |
| Participant information sheet | Not available in web format, please use the contact details to request a patient information sheet. |
| Scientific title | Predictors of psychological treatment outcomes for CMHP in IAPT |
| Study acronym | PROPEL |
| Study hypothesis | 1. What are the predictors of psychological treatment outcomes for common mental health problems in adults (18+ years) in the Improving Access to Psychological Therapies (IAPT) services? 2. Do these factors affect psychological treatment outcomes differently for older (65+ years) and working-age adults (18-64 years)? |
| Ethics approval(s) | Approved 24/12/2021, South Central-Hampshire B Research Ethics Committee (Health Research Authority, 2 Redman Place, Stratford, London, E20 1JQ, UK; +44 20 7104 8289; hampshireb.rec@hra.nhs.uk), ref: 21/SC/0387 |
| Condition | Common mental health problems, such as depression and/or any anxiety disorder, e.g. generalised anxiety disorder, panic disorder, phobias, PTSD, OCD. |
| Intervention | Participants will be invited to take part in the study after having been accepted into the IAPT service, but before the start of treatment. Once consented, participants will be asked to complete a questionnaire with different measures - these form the baseline measures. After the completion of treatment, a set of routinely collected measures by IAPT will be obtained, including pre- and post-treatment symptom severity. Analyses will be run to ascertain if any factors obtained at baseline are associated with treatment outcome. The total duration of treatment and follow-up depends on the individual treatment each participant receives and how many sessions they attend. |
| Intervention type | Behavioural |
| Primary outcome measure | Recovery and change in symptom severity as measured by the scores on the corresponding scale for each presenting problem (below). These measures are routinely taken in the IAPT service before the start of therapy (T0) and post-therapy (T1): 1. Depression symptom severity measured using The Patient Health Questionnaire (PHQ-9) 2. Generalised anxiety measured using the Generalised Anxiety Disorder Assessment (GAD-7) 3. Obsessive-compulsive disorder measured using the Obsessive-Compulsive Inventory (OCI) 4. Social phobia measured using the Social Phobia Inventory (SPIN) 5. Agoraphobia measured using the Agoraphobia-Mobility Inventory (MI) 6. PTSD measured using PTSD Checklist for DSM-5 (PCL-5) 7. Panic disorder severity measured using the Panic Disorder Severity Scale (PDSS) |
| Secondary outcome measures | Daily occupational and social functioning measured using The Work and Social Adjustment Scale (WSAS) before the start of therapy (T0) and post-therapy (T1). |
| Overall study start date | 24/12/2021 |
| Overall study end date | 31/03/2024 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Lower age limit | 18 Years |
| Sex | Both |
| Target number of participants | 700 |
| Total final enrolment | 1218 |
| Participant inclusion criteria | 1. Be aged 18 years or over 2. Are offered treatment in the IAPT service in step 2 or step 3 of depression and/or an anxiety disorder 3. Read and understand English at the required level in order to respond to the PIS and the questionnaire |
| Participant exclusion criteria | 1. Patients under the age of 18 years |
| Recruitment start date | 10/06/2022 |
| Recruitment end date | 31/03/2023 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centres
Swandean
Arundel Road
Worthing
BN13 3EP
United Kingdom
Newbridge Hill
Bath
BA1 3QE
United Kingdom
Beverley Road
Willerby
Hull
HU10 6ED
United Kingdom
C E M E Centre
Marsh Way
Rainham
RM13 8GQ
United Kingdom
Pinewood PLACE
Dartford
DA2 7WG
United Kingdom
Glenburnie Road
London
SW17 7DJ
United Kingdom
Fulbourn Hospital
Fulbourn
Cambridge
CB21 5EF
United Kingdom
9 Alie Street
London
E1 8DE
United Kingdom
Calmore
Southampton
SO40 2RZ
United Kingdom
Skimped Hill Lane
Bracknell
RG12 1BQ
United Kingdom
The Countess of Chester Health Park
Liverpool Road
Chester
CH2 1BQ
United Kingdom
Victoria Road
Saltaire
Shipley
BD18 3LD
United Kingdom
Bursledon Road
Southampton
SO19 8BR
United Kingdom
Kingsway Hospital
Kingsway
Derby
DE22 3LZ
United Kingdom
Randalls Road
Leatherhead
KT22 7AD
United Kingdom
Elm Grove
Brighton
BN2 3EW
United Kingdom
Beaconsfield Close
Hatfield
AL10 8YE
United Kingdom
Drayton High Road
Norwich
NR6 5BE
United Kingdom
Gosforth
Newcastle upon Tyne
NE3 3XT
United Kingdom
St Georges Hospital
Corporation Street
Stafford
ST16 3SR
United Kingdom
4-6 Nuffield Road
Nuffield Industrial Estate
Poole
BH17 0RB
United Kingdom
Sponsor information
University/education
Falmer
Brighton
BN1 9RH
England
United Kingdom
| Phone | +44(0)1273 872748 |
|---|---|
| researchsponsorship@sussex.ac.uk | |
| Website | http://www.sussex.ac.uk/ |
"ROR" |
https://ror.org/00ayhx656 |
Funders
Funder type
Charity
Government organisation / Trusts, charities, foundations (both public and private)
- Alternative name(s)
- Mental Health Research in United Kingdom, MHRUK
- Location
- United Kingdom
Results and Publications
| Intention to publish date | 31/12/2024 |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Data sharing statement to be made available at a later date |
| Publication and dissemination plan | Planned publication in a high-impact peer-reviewed journal. |
| IPD sharing plan | The data sharing plans for the current study are unknown and will be made available at a later date. |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol file | version 6 | 04/08/2022 | 22/12/2022 | No | No |
| HRA research summary | 28/06/2023 | No | No | ||
| Statistical Analysis Plan | 15/08/2024 | No | No |
Additional files
Editorial Notes
15/08/2024: The statistical analysis plan was uploaded as an additional file.
13/03/2024: The following changes have been made:
1. The intention to publish date was changed from 01/09/2024 to 31/12/2024.
2. The total final enrolment was added.
16/02/2023: The study setting has been changed from ‘Other’.
22/12/2022: Trial's existence confirmed by South Central-Hampshire B Research Ethics Committee.
