Randomised crossover trial to determine whether a beta blocker and an Angiotensin Converting Enzyme (ACE) inhibitor have independent effects in lowering blood pressure
| ISRCTN | ISRCTN97280940 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN97280940 |
| Secondary identifying numbers | P3/04/040 |
- Submission date
- 02/03/2007
- Registration date
- 16/05/2007
- Last edited
- 03/05/2011
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Circulatory System
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English Summary
Not provided at time of registration
Contact information
Dr David Wald
Scientific
Scientific
Wolfson Institute of Preventive Medicine
Charterhouse Square
London
EC1 M6BQ
United Kingdom
| d.s.wald@qmul.ac.uk |
Study information
| Study design | Randomised, placebo-controlled, crossover trial. |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Hospital |
| Study type | Not Specified |
| Scientific title | |
| Study acronym | CTBP (Combination Therapy Blood Pressure) Trial |
| Study hypothesis | Randomised, crossover trial to determine whether a beta blocker and an ACE inhibitor have independent effects in lowering blood pressure. |
| Ethics approval(s) | East London Local Research Ethics Committee on 04/05/2004 (ref: DAI/MY/P304040) |
| Condition | Cardiovascular disease |
| Intervention | All participants received each of the following interventions: 1. Atenolol 25 mg 2. Lisinopril 5 mg 3. Atenolol 25 mg + lisinopril 5 mg 4. Placebo sequentially in a random sequence. |
| Intervention type | Other |
| Primary outcome measure | Systolic and diastolic blood pressure. |
| Secondary outcome measures | Adverse effects. |
| Overall study start date | 14/04/2004 |
| Overall study end date | 14/12/2004 |
Eligibility
| Participant type(s) | Patient |
|---|---|
| Age group | Adult |
| Sex | Both |
| Target number of participants | 60 |
| Participant inclusion criteria | 1. Men or women over age 40 2. Blood presssure over 100/60 mmHg |
| Participant exclusion criteria | 1. Peripheral vascular disease 2. Asthma 3. Atrial Fibrillation (AF) |
| Recruitment start date | 14/04/2004 |
| Recruitment end date | 14/12/2004 |
Locations
Countries of recruitment
- United Kingdom
Study participating centre
Wolfson Institute of Preventive Medicine
London
EC1 M6BQ
United Kingdom
EC1 M6BQ
United Kingdom
Sponsor information
Queen Mary University of London (UK)
University/education
University/education
Charterhouse Square
London
EC1 M6BQ
United Kingdom
| gerry.leonard@bartsandthelondon.nhs.uk | |
"ROR" |
https://ror.org/026zzn846 |
Funders
Funder type
Other
Investigator-funded (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/11/2008 | Yes | No |
