Plasma glucagon-like peptide (GLP) (7-36) amide response to low versus high glycaemic index drinks in Type II diabetic subjects and non-diabetic controls.
| ISRCTN | ISRCTN41341840 |
|---|---|
| DOI | https://doi.org/10.1186/ISRCTN41341840 |
| Secondary identifying numbers | N0016132030 |
- Submission date
- 30/09/2004
- Registration date
- 30/09/2004
- Last edited
- 10/03/2011
- Recruitment status
- No longer recruiting
- Overall study status
- Completed
- Condition category
- Nutritional, Metabolic, Endocrine
Prospectively registered
Protocol
Statistical analysis plan
Results
Individual participant data
Plain English Summary
Not provided at time of registration
Contact information
Miss Joanne Milton
Scientific
Scientific
Nutrition and Dietetics Department
Imperial College
Hammersmith Campus
London
W12 0HS
United Kingdom
| Phone | +44 (0)208 383 5802 |
|---|---|
| JMilton@hhnt.org |
Study information
| Study design | Randomised controlled trial |
|---|---|
| Primary study design | Interventional |
| Secondary study design | Randomised controlled trial |
| Study setting(s) | Not specified |
| Study type | Not Specified |
| Scientific title | |
| Study hypothesis | 1. To investigate the effects of drinks of differing glycaemic index (GI) on plasma GLP-1 concentrations and subsequent metabolic responses to a meal. 2. To determine if a low GI drink will cause a greater increase in postprandial GLP-1 concentrations and result in improved metabolic response compared to a high GI drink or water at a subsequent meal. |
| Ethics approval(s) | Not provided at time of registration |
| Condition | Nutritional, Metabolic, Endocrine: Diabetes |
| Intervention | Not provided at time of registration |
| Intervention type | Other |
| Primary outcome measure | Diet is the first line treatment for Type 2 diabetes, however the optimal diet to promote good glycaemic control is still debated. GLP-1 is being investigated as an agent for the treatment of diabetes, however it has its shortcomings due to its short half life in humans. A specific food that could be consumed before a meal to stimulate release of GLP-1 and thus improve glycaemic control would be highly beneficial to patients, and potentially have fewer side effects and be less invasive than subcutaneous administration of the hormone. |
| Secondary outcome measures | Not provided at time of registration |
| Overall study start date | 10/09/2003 |
| Overall study end date | 09/09/2007 |
Eligibility
| Participant type(s) | Healthy volunteer |
|---|---|
| Age group | Adult |
| Sex | Not Specified |
| Target number of participants | 24 |
| Participant inclusion criteria | 1. 12 diabetics and 12 healthy volunteers 2. Ages 30-65 |
| Participant exclusion criteria | Not provided at time of registration |
| Recruitment start date | 10/09/2003 |
| Recruitment end date | 09/09/2007 |
Locations
Countries of recruitment
- England
- United Kingdom
Study participating centre
Nutrition and Dietetics Department
London
W12 0HS
United Kingdom
W12 0HS
United Kingdom
Sponsor information
Department of Health
Government
Government
Richmond House
79 Whitehall
London
SW1A 2NL
United Kingdom
| Website | http://www.dh.gov.uk/Home/fs/en |
|---|
Funders
Funder type
Government
Hammersmith Hospital NHS Trust (UK)
No information available
Results and Publications
| Intention to publish date | |
|---|---|
| Individual participant data (IPD) Intention to share | No |
| IPD sharing plan summary | Not provided at time of registration |
| Publication and dissemination plan | Not provided at time of registration |
| IPD sharing plan |
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Results article | results | 01/12/2007 | Yes | No |
