Contact information
Type
Scientific
Contact name
Dr Sue Moss
ORCID ID
Contact details
Professor of Cancer Epidemiology
Centre for Cancer Prevention
Queen Mary University of London
Wolfson Institute of Preventive Medicine Charterhouse Square London
London
EC1M 6BQ
United Kingdom
+44 (0)207 882 5841
s.moss@qmul.ac.uk
Additional identifiers
EudraCT/CTIS number
IRAS number
ClinicalTrials.gov number
Secondary identifying numbers
G9000793
Study information
Scientific title
UKCCCR trial to study the effect on breast cancer mortality of annual mammographic screening starting at age 40
Acronym
The 'Age' trial
Study hypothesis
To determine the effectiveness of mammographic screening starting at age 40, compared with starting at age 50, in reducing mortality from breast cancer.
Ethics approval(s)
Ethics approval from Central London REC 98/2/40.
Study design
Randomised controlled trial
Primary study design
Interventional
Secondary study design
Randomised controlled trial
Study setting(s)
Hospital
Study type
Screening
Patient information sheet
Not available in web format, please use the contact details below to request a patient information sheet
Condition
Breast cancer
Intervention
Women in the intervention group are offered annual screening by mammography until the year of their 48th birthday. Screening is by 2-view mammography at 1st screen and single view subsequently. All women in both intervention and control groups will be invited for screening in the NHSBSP between the age of 50-52.
Intervention type
Other
Primary outcome measure
Deaths from breast cancer in women free of the disease at trial entry in the two groups. Information on prognostic factors of all breast cancers is also collected.
Secondary outcome measures
Not provided at time of registration
Overall study start date
30/07/1990
Overall study end date
31/12/2010
Reason abandoned (if study stopped)
Eligibility
Participant inclusion criteria
Women aged 40-41 identified from Health Authorities registers
Participant type(s)
Patient
Age group
Adult
Sex
Female
Target number of participants
195,000. Recruitment ceased at 160,000
Participant exclusion criteria
Women under care for breast cancer may be removed from the prior notification list by the GPs prior to randomisation
Recruitment start date
30/07/1990
Recruitment end date
31/12/2010
Locations
Countries of recruitment
England, United Kingdom
Study participating centre
Queen Mary University of London
London
EC1M 6BQ
United Kingdom
Sponsor information
Organisation
Medical Research Council (MRC) (UK)
Sponsor details
20 Park Crescent
London
W1B 1AL
United Kingdom
+44 (0)20 7636 5422
clinical.trial@headoffice.mrc.ac.uk
Sponsor type
Research council
Website
Funders
Funder type
Research council
Funder name
Medical Research Council (MRC) (UK)
Alternative name(s)
UK Medical Research Council, MRC
Funding Body Type
government organisation
Funding Body Subtype
National government
Location
United Kingdom
Funder name
Long-term follow up funded by National Institute for Health Research (NIHR) / Health Technology Assessment (HTA)
Alternative name(s)
Funding Body Type
Funding Body Subtype
Location
Results and Publications
Publication and dissemination plan
Not provided at time of registration
Intention to publish date
Individual participant data (IPD) Intention to share
No
IPD sharing plan
IPD sharing plan summary
Not provided at time of registration
Study outputs
| Output type | Details | Date created | Date added | Peer reviewed? | Patient-facing? |
|---|---|---|---|---|---|
| Protocol article | protocol | 01/07/1999 | Yes | No | |
| Other publications | Implications of pathologist concordance | 01/03/2002 | Yes | No | |
| Results article | results | 09/12/2006 | Yes | No | |
| Other publications | assessment of contamination in the control group: | 01/04/2010 | Yes | No | |
| Results article | results | 01/09/2015 | Yes | No | |
| Results article | results | 01/04/2016 | Yes | No | |
| Results article | results | 01/09/2020 | 19/08/2020 | Yes | No |